解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The metastasis-associated (MTA) gene family is a critical component of the nucleosome remodeling and histone deacetylase complex, and plays an important role in metastatic processes. We systematically evaluated dysregulation of the MTA family to clarify their clinical significance in gastric cancer (GC). One hundred a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5054
更新日期:2016-10-01 00:00:00
abstract::Epigenetic anticancer drugs such as histone deacetylase (HDAC) inhibitors have been combined with existing anticancer drugs for synergistic or additive effects. In the present study, we found that a very low concentration of depsipeptide, an HDAC inhibitor, potentiated the antitumor activity of 5-fluorouracil (5-FU) i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5008
更新日期:2016-10-01 00:00:00
abstract::The long non-coding RNA MFI2 antisense RNA is overexpressed in human cancer tissues and its increased expression is associated with occurrence and metastasis of cancer. However, the underlying mechanism in evolution and progression of human osteosarcoma is not well known. In the present study, we aimed to evaluate the...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5013
更新日期:2016-10-01 00:00:00
abstract::Hydrogen sulfide (H2S), regarded as the third gaseous transmitter, mediates and induces various biological effects. The present study investigated the effects of H2S on multiple myeloma cell progression via amplifying the activation of Akt pathway in multiple myeloma cells. The level of H2S produced in multiple myelom...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5014
更新日期:2016-10-01 00:00:00
abstract::The androgen receptor (AR) plays an essential role in the development and progression of prostate cancer. Castration-resistant prostate cancer (CRPC) is a consequence of androgen deprivation therapy. Unchecked CRPC followed by metastasis is lethal. Some CRPCs show decreased AR gene expression due to epigenetic mechani...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.5000
更新日期:2016-10-01 00:00:00
abstract::Cholangiocarcinoma (CCA) is the second most common hepatic cancer with high resistance to current chemotherapies and extremely poor prognosis. The present study aimed to examine the effects of schisandrin B (Sch B) on CCA cells both in vitro and in vivo and to examine its underlying mechanism. We found that Sch B inhi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4992
更新日期:2016-10-01 00:00:00
abstract::Aberrant glycosylation, a common feature of malignant alteration, is partly due to changes in the expression of glycosyltransferases, including β1,3-N-acetyl-glucosaminyltrans-ferase 8 (β3Gn‑T8), which synthesizes poly-N-acetyllactosamine (poly-LacNAc) chains on β1,6 branched N‑glycans. Although the role of β3Gn‑T8 in...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4959
更新日期:2016-09-01 00:00:00
abstract::Lung cancer is one of the most common cancers worldwide and accounts for 28% of all cancer-related deaths. The expression of the β2‑adrenergic receptor (β2‑AR), one of the stress‑inducible receptors, has been reported to be closely correlated with malignant tumors. However, the role of β2‑AR activation in human lung e...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4966
更新日期:2016-09-01 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and mainly originates from an accumulation of abnormal B cells caused by the dysregulation of cell proliferation and apoptosis rates. The aberration of apoptosis-related genes in CLL cells results in defective apoptosis of CLL cells i...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4950
更新日期:2016-09-01 00:00:00
abstract::Currently, there are emerging multiple studies on human epididymis protein 4 (HE4) in ovarian cancer. HE4 possesses higher sensitivity and specificity than CA125 in the confirmative early diagnosis for ovarian cancer. Although much attention has been given to explore its clinical application, research of the basic mec...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4926
更新日期:2016-09-01 00:00:00
abstract::Oxymatrine, a traditional Chinese herb extracted from Sophora flavescens Ait., displays strong anti-inflammatory and anticancer activities, but how oxymatrine exhibits anticarcinogenic effects in human colorectal cancer (CRC) remains uncertain. The present study aimed to elucidate the exact mechanism by which oxymatri...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4927
更新日期:2016-09-01 00:00:00
abstract::Burkitt's lymphoma (BL) is a fast growing cancer of the human lymphatic system, and an extremely invasive B-cell non-Hodgkin's lymphoma. We explored the mechanism of apoptosis in Raji cells associated with the post-transcriptional regulation factors. To confirm that the predicted microRNA-520a (miR-520a) is matched wi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4975
更新日期:2016-09-01 00:00:00
abstract::lncRNA metastasis-associated lung adencarcinoma transcript 1 (MALAT1) plays an important role in the metastasis of lung cancer. Yet, its role in bone metastasis and the related mechanism remain unknown. The present study aimed to investigate the role of lncRNA MALAT1 in the bone metastasis of non-small cell lung cance...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4909
更新日期:2016-09-01 00:00:00
abstract::The growth inhibitory effects of bufadienolide compounds were investigated in two intractable cancer cells, a human glioblastoma cell line U-87 and a pancreatic cancer cell line SW1990. Among four bufadienolide compounds, a dose-dependent cytotoxicity was observed in these cancer cells after treatment with gamabufotal...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4946
更新日期:2016-09-01 00:00:00
abstract::The objective of the present study was to explore the in vitro and in vivo anticancer effects of Platycodin D (PD), derived from Platycodin grandiflorum, on highly metastatic MDA-MB-231 breast cancer cells. Using the MTT assay, we found that PD inhibited MDA-MB-231 cell growth in a concentration-dependent manner, with...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4935
更新日期:2016-09-01 00:00:00
abstract::Mathematical modeling and serial magnetic resonance imaging (MRI) used to calculate patient-specific rates of tumor diffusion, D, and proliferation, ρ, can be combined to simulate glioblastoma multiforme (GBM) growth. We showed that the proportion and distribution of tumor cells below the MRI threshold are determined ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4878
更新日期:2016-08-01 00:00:00
abstract::Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Frequent metastasis and recurrence are the main reasons for the poor prognosis of PC patients. Thus, the discovery of new biomarkers and wider insights into the mechanisms involved in pancreatic tumorigenesis and metastasis is cruc...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4865
更新日期:2016-08-01 00:00:00
abstract::Statins are the most effective drugs used in the reduction of intracellular synthesis of cholesterol. Numerous studies have confirmed that statins reduce the risk of multiple types of cancers. Statin use in cancer patients is associated with reduced cancer-related mortality. Epithelial-to-mesenchymal transition (EMT),...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4897
更新日期:2016-08-01 00:00:00
abstract::Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma. A20 and mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) are known to be related to DLBCL pathogenesis and progression. This study aimed to assess the effects of phorbol myristate acetate/ionomycin (PMA/IONO) on the growth a...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4899
更新日期:2016-08-01 00:00:00
abstract::As one of the most common malignancies, esophageal squamous cell carcinoma (ESCC) is ranked as the sixth leading cause of cancer-related death worldwide. In our previous study, by employing cDNA microarray analysis, semaphorin 3B (SEMA3B) was found to be significantly downregulated in ESCC. In the present study, SEMA3...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4901
更新日期:2016-08-01 00:00:00
abstract::Emodin is an active ingredient derived from root and rhizome of Rheum palmatum L and many studies have reported that it exhibits anticancer effects in a number of human tumors. However, there is little information demonstrating the possible effects of emodin on the proliferation and apoptosis of hepatocellular carcino...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4861
更新日期:2016-08-01 00:00:00
abstract::Metastasis is the main cause of death in osteosarcoma. Targeting the process of metastasis is a main strategy for osteosarcoma therapy. As a traditional Chinese medicine, Zanthoxylum nitidum (Roxb) has been applied to treat various diseases, including cancer. However, no evidence has been shown on the anti-metastasis ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4846
更新日期:2016-08-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a highly vascular tumor, and treatment options for patients of advanced-stage are limited. Nitric oxide (NO), which is derived from endothelial nitric oxide synthase (eNOS), provides crucial signals for angiogenesis in the tumor microenvironment. Tetrahydrobiopterin (BH4) is an essent...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4850
更新日期:2016-08-01 00:00:00
abstract::The adenovirus vector-based cancer gene therapy is controversial. Low transduction efficacy is believed to be one of the main barriers for the decreased expression of coxsackie and adenovirus receptor (CAR) on tumor cells. However, the expression of CAR on primary tumor tissue and tumor tissue survived from treatment ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4870
更新日期:2016-08-01 00:00:00
abstract::TRIM58 (tripartite motif containing 58) has been reported as a novel methylated gene in hepatocellular carcinoma (HCC) by methylation microarrays. However, its associations with mRNA expression and clinicopathological characteristics have not been evaluated. In this study, we explored the potential clinical implicatio...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4871
更新日期:2016-08-01 00:00:00
abstract::Although antiestrogens significantly improve the survival of patients with ER-positive breast cancer, therapeutic resistance remains a major limitation. The combinatorial use of antiestrogen with other therapies was proposed to increase their efficiency and more importantly, to prevent or delay the resistance phenomen...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4873
更新日期:2016-08-01 00:00:00
abstract::Regulated intramembrane proteolysis of epithelial cell adhesion molecule (EpCAM) results in shedding of the extracellular domain (EpEX) and release of the intra-cellular domain (EpICD) into the cytoplasm. Released EpICD associates with FHL2, β-catenin and Lef-1 to form a nuclear complex and triggers oncogenic signalin...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4789
更新日期:2016-07-01 00:00:00
abstract::Previous studies have shown that S100 calcium-binding protein A8 (S100A8) contributes to the survival and migration of colorectal cancer (CRC) cells. However, whether S100A8 participates in the progression and metastasis of CRC via the regulation of macrophages in the tumor inflammatory microenvironment remains unknow...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4790
更新日期:2016-07-01 00:00:00
abstract::Protocadherin-10 (PCDH10), a member of non-clustered protocadherin family which plays important roles in calcium-dependent cell-cell signal transduction and adhesion. PCDH10 functions as a tumor suppressor gene and its expression is downregulated by promoter methylation in many malignances. In the present study, we ex...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4793
更新日期:2016-07-01 00:00:00
abstract::Hypoxia always exists in the processes involved in the development of lung cancer and contributes to an acidic microenvironment. Despite that hypoxia in the tumor microenvironment is associated with the formation of chemotherapeutic resistance, the exact role of an acidic microenvironment in the development of hypoxia...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4827
更新日期:2016-07-01 00:00:00
abstract::EGFR and KRAS mutations are the two most common driver mutations in non-small cell lung cancer (NSCLC). Molecular target-based therapy using small molecules such as gefitinib has been used for inhibiting EGFR with good initial responses; however, drug resistance is common when using a mono-targeting strategy. At prese...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4770
更新日期:2016-07-01 00:00:00
abstract::WNT5B is a member of the WNT family that has been reported to be overexpressed in a variety of cancer cell lines and tissues, including colorectal cancer (CRC). However, the potential roles of WNT5B in tumorigenesis have not been reported. In the present study, the WNT5B gene was transfected into CRC cells and generat...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4772
更新日期:2016-07-01 00:00:00
abstract::The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate epithelial cells. Expression of this receptor is lost as prostate can...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4832
更新日期:2016-07-01 00:00:00
abstract::Cumulative evidence suggests that long non-coding RNAs (lncRNAs) may be good biomarkers in various types of tumors. In the present study, we mined lncRNA expression profiling in 739 lung cancer patients from Gene Expression Omnibus (GEO) datasets. A risk score model was constructed based on the expression data of thes...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4817
更新日期:2016-07-01 00:00:00
abstract::Accumulating evidence has shown that aberrantly expressed microRNAs (miRNAs) are associated with tumor development and progression. Our previous study found that microRNA-375 (miR-375) was downregulated in colorectal cancer (CRC), but little is known concerning the role of miR-375 and the related mechanism in CRC deve...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4834
更新日期:2016-07-01 00:00:00
abstract::The aim of the present study was to uncover potential prognostic microRNA (miRNA) markers in head and neck squamous cell carcinoma (HNSCC). miRNA expression profile and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Survival analysis was conducted by Kaplan-Meier method. Then, candidate prog...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4698
更新日期:2016-06-01 00:00:00
abstract::In humans, four tropomyosin genes (TPM1, TPM2, TPM3, and TPM4) are known to produce a multitude of isoforms via alternate splicing and/or using alternate promoters. Expression of tropomyosin has been shown to be modulated at both the transcription and the translational levels. Tropomyosins are known to make up some of...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4732
更新日期:2016-06-01 00:00:00
abstract::Mutations in the epidermal growth factor receptor (EGFR) make lung adenocarcinoma cells sensitive to EGFR tyrosine kinase inhibitors (TKIs). Long-term cancer therapy may cause the occurrence of acquired resistance to EGFR TKIs. Long non-coding RNAs (lncRNAs) play important roles in tumor formation, tumor metastasis an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4758
更新日期:2016-06-01 00:00:00
abstract::Anaplastic thyroid cancer is one of the most aggressive human malignancies and is resistant to multimodal treatments. The expression of h-prune, the human homologue of Drosophila prune, has been reported to be correlated with progression and aggressiveness in various cancers including breast, colorectal and pancreatic...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4759
更新日期:2016-06-01 00:00:00
abstract::The process of angiogenesis is essential for tumor development and metastasis. Vascular endothelial growth factor (VEGF), which is overexpressed in most human cancers, has been demonstrated to be a major modulator of angiogenesis. Thus, inhibition of VEGF signaling has the potential for tumor anti-angiogenic therapy. ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2016.4761
更新日期:2016-06-01 00:00:00